Neutralize os efeitos do Stress oxidativo com produtos da OXIS International

Combata os efeitos do stress oxidativo com produtos da OXIS International, Inc que desenvolve e vende produtos terapeuticos.

A OXIS International é uma empresa direcionada para o desenvolvimento de tecnologias e produtos para investigação, diagnóstico, tratamento e prevenção de doenças associadas a Radicais Livres e ROS - doenças do Stresse Oxidativo. Através da sua divisão de Produtos para a Saúde ela desenvolve, fabrica e comercializa produtos e tecnologia relacionada com o Stresse Oxidativo.

O Stress oxidativo é uma condição biológica em que ocorre desequilíbrio entre a produção de espécies reactivas de oxigénio e a sua desintoxicação através de sistemas biológicos que as removam ou reparem os danos por elas causados. Todos os organismos vivos possuem um ambiente intracelular de natureza redutora, existindo um equilíbrio entre as formas oxidada e reduzida de moléculas como o NADH, equilíbrio esse mantido por enzimas à custa de energia metabólica. Perturbações neste equilíbrio redox podem provocar a produção de peróxidos e radicais livres que danificam todos os componentes celulares, incluindo proteínas, lípidos e o ADN.

Em humanos, o stress oxidativo encontra-se ligado a diversas doenças, como a aterosclerose, a doença de Parkinson e a doença de Alzheimer.

Os produtos da OXIS International concentram em substâncias naturais de proteção, uma vez que são mais suscetíveis de ser seguro e eficaz.

A Oxis tem vários compostos terapêuticos que estão disponíveis para serem licenciados, incluindo anti- inflamatórios e antioxidante, várias soluções terapêuticas com potenciais aplicações no tratamento de doenças neurodegenerativas (Alzheimer e Parkinson ), doenças cardiovasculares , diabetes e outras condições.

Para saber mais sobre a OXIS International:

Site Oficial OXIS: http://www.oxis.com
Twiter Oficial: Oxis on Twitter
Facebook: Oxis on facebook

The most buzzed about games of E3 2010

Los Angeles, California (CNN) -- From motion controls to cloud-computing solutions and 3-D gaming technology, there was no shortage of futuristic goodies on display at this year's interactive entertainment industry confab E3.

But with so much attention being paid to hardware innovations like Sony's PlayStation Move and Microsoft's Kinect gesture-tracking interfaces -- as well as Nintendo's new 3DS handheld -- it's easy to forget that it's really all about the games.

Available systems such as the PC, PlayStation 3, PSP, Nintendo DSi, Wii and Xbox 360 are still the tools of almost all gamers, and probably will be for several years.

These systems, of course, would be nothing without jaw-dropping software titles to show off their potential.

Among the hundreds of promising outings on display at E3, the following five were among the most buzzed-about titles by critics, fans and industry insiders. Each promises to keep millions of thumbs happily waggling in the months to come.

"Killzone 3D"
Sony hopes that this stunning first-person shooter -- a PS3 exclusive which features visceral combat in a bleak futuristic setting -- will do for 3-D games what "Avatar" did for 3-D movies. It aims to make its case by adding jetpacks and destructible environments, plus upping visual fidelity to insane levels and introducing support for the PlayStation Move.

Swirling snow, glowing-eyed adversaries and flying bullets will be the order of the day when it ships in February 2011.

"Rage"
Noted developer id Software wrote the book on run and gun outings with classics like "Wolfenstein 3D," "Doom" and "Quake." Now the studio is turning its attention toward crafting a stunningly beautiful, "Mad Max" style post-apocalyptic wasteland where you can alternately blow slavering crazies away or speed along in playable vehicles enjoying the sun-scorched scenery.

While only a brief demo of the PC and PS3 title is being shown at the conference, it's already got fans' antennas up.

"The Legend of Zelda: Skyward Sword"
Wii owners have been feverishly waiting several years for a new installment in the popular series of whimsical, fantasy dungeon-crawling action-adventures.

They'll have to wait a little longer, as this new Wii title isn't due until 2011. But thanks to the highly accurate Wii MotionPlus movement-sensing peripheral, which allows you to control a bow or sword through physical gestures, plus new items like a flying beetle and whip, it promises several engaging new enhancements.

"Portal 2"
This update takes the popular puzzle game, wherein you instantly create wormholes to solve puzzles by teleporting between two locations, and greatly expands the formula. The game now adds physical effects like air currents to travel between these gates, and paint that can change the physical properties of objects, making them slicker or bouncier.

Coming for PC, PS3 and Xbox 360 in 2011, it's expected to cheerfully confound critics and fans alike.

"Dead Space 2"
It's a futuristic sci-fi survival horror outing heavy on the trigger-mashing action wherein hero Isaac Clarke must blow the limbs off grotesque monsters that assault him using wicked claws or toxic spit.

Traveling around in high-tech and zero-gravity environments in an armored suit, you'll solve puzzles and squirm as swarms of foes dance around your pitiful spear gun.

Be sure to pack an extra pair of underwear when it ships for PC, PS3 and Xbox 360 on January 25, 2011.

Gardner executed by firing squad

Draper, Utah (CNN) -- Convicted killer Ronnie Lee Gardner was executed early Friday by firing squad, the Utah Department of Corrections said.

Gardner, 49, is only the third person in 33 years to die by firing squad in the United States.

He was killed at 12:20 a.m. MST (2:20 a.m. ET), a Corrections Department spokesman said.

A hood was placed over Gardner's head and a paper target pinned to his chest. He was heavily restrained as a five-person firing squad took aim at the target and shot him, witnesses said.

Journalists who witnessed the shooting said it happend quickly. One reporter said she noticed that Gardner moved after he was shot.

"It was over pretty quickly," said Cheryl Worsley, a local radio reporter. "It was cleaner than I expected. It was fast. But he moved. He moved a little bit, and to some degree that bothers me."

Outside the prison in Draper Utah, there was a candlelight vigil attended by members of Gardner's family.

"He did things bad in the past, but now he realizes what he did and he changed the last couple of years," said his granddaughter Darian Gardner, breaking into tears. "I got to know him the last couple of years. It sucks when you have to say goodbye to someone that is like your best friend."

The execution came after Gardner's last-ditch efforts to save himself had failed.
Video: Death row inmate executed
Video: Death by firing squad
RELATED TOPICS

* Ronnie Lee Gardner
* Capital Punishment
* U.S. Supreme Court

The U.S. Supreme Court rejected a request Thursday to temporarily stay the execution. Utah Gov. Gary Herbert rejected two appeals by Gardner's attorneys to stop the execution, saying he had every chance to present his case.

Gardner, 49, was convicted for the shooting death of attorney Michael Burdell during a botched escape attempt from custody in 1985 at a Salt Lake City, Utah, courthouse.

Among the claims Gardner raised in his appeals is that he has been a death-row inmate for too long.

"He asserts that executing him now, after nearly 25 years on death-row in Utah, so lacks retributive or deterrent value that it violates the Eighth Amendment," Andrew Parnes, Gardner's lawyer, told the high court.

A federal judge late Tuesday declined to block the execution, after Gardner claimed the procedures related to a two-day commutation hearing held by the state Board of Pardons and Parole last week violated his civil rights. The parole board Monday declined to commute Gardner's sentence to life in prison, and the Utah Supreme Court on Tuesday also denied his request for a stay.

Gardner was the third person to die by rifle fire, all in Utah, since the Supreme Court restored the death penalty in 1976. He had a long history of escapes and was slipped a gun before he fatally shot Burdell on April 2, 1985. He was at the courthouse for a pre-trial hearing in the 1984 slaying of Melvyn Otterstrom, who was killed at the Salt Lake City bar where he was working to earn extra money.

Corrections officials announced Gardner had consumed his last meal Tuesday night at 6:30 p.m., and chose to fast prior to the anticipated execution. His dinner included steak, lobster, 7-Up, apple pie and vanilla ice cream.

Man jailed in actor Jeremy London's kidnapping

(CNN) -- Actor Jeremy London escaped from armed carjackers who kidnapped him along a Palm Springs, California, roadside last week, police said.

London said the kidnappers forced him to "use illegal drugs," according to a Palm Springs Police statement.

London, 37, is known for his television work, including five seasons as Griffin Holbrook on the hit series "Party of Five."

The actor told police that "several men" approached him as he was changing a flat tire on Friday, according to the the police statement. After they helped change the tire, London offered them a ride home, police said.

"A short time later, he was held at gunpoint in the vehicle by one of the occupants," police said. "The gunman forced London to drive to various locations throughout the city, purchase alcohol and use illicit drugs."

London eventually escaped the vehicle and called police, they said.

Police said they found London's vehicle in a residential area of Palm Springs and they arrested one suspect later that day.

Brian Adams, a 26-year-old Palm Springs man, was charged with kidnapping, possession of stolen property, and vehicle theft and carjacking in connection with this case, police said.

London talked to People magazine earlier this year about his battle with a prescription drug addiction, which he said sent him to rehab last year.

London began his professional acting career playing Nathan Bedford in TV's "I'll Fly Away," a role he won in 1991 after his twin brother, Jason London, turned it down.

He was also a regular in "7th Heaven" as Chandler Hampton, starting in 2002.

'Toy Story 3' knocks it out of the playbox

(CNN) -- How should a tortilla move? Trust Pixar to ask the important questions and to come up with the most inspired answers, too.

Unsteadily, at first, in a floppy, folding, undulating furl, on detachable legs accustomed to the rotund corporeal bulk of Mr. Potato Head (the potato being indisposed at the time).

Nobody speaks body language more eloquently than Pixar.

In another inspired touch, space ranger toy Buzz Lightyear is inadvertently rebooted for the Hispanic market. Not only does he switch to fluent Spanish, he accompanies his newly ardent protestations of love to cowgirl Jessie with flamboyant flamenco finger clicks and swiveling hips. He's an intergalactic toreador of love.

Nifty moves are one thing, but everybody knows that by the second sequel -- or "threequel" if you prefer -- even the strongest film franchise is venturing onto shaky ground. (Not to say there aren't exceptions.)

But in any case, conventional wisdom never seems to apply to Pixar, the digital animation giant that only ever seems to produce winners: "WALL-E," "Cars," "Up" and "Monsters, Inc." to name just a few.

It was "Toy Story" that started Pixar's remarkable run 15 years ago, but the angsty devotion of Andy's cowboy doll and his friends (a slinky dog, a cowardly T Rex and a piggy bank named Hamm among them) as they await their inevitable retirement remains as poignant today as it did then. Maybe more so, now that a generation of kids have grown up with these characters, and, in some cases, probably have grown out of them.

iReport: Kids review "Toy Story 3"

In "Toy Story 3", Woody and Buzz (voiced by Tom Hanks and Tim Allen, as always) remain unchanged, as good as new in fact, but their owner, Andy, is 17 now and moving on to college. His mom wants his room cleared, and a misunderstanding consigns the toys to Sunnyside Daycare.

Initially the idea of all-day play seems too good to be true, but Sunnyside has a dark side: it's "a place of ruin and despair", a pre-kindie pastel-colored gulag presided over by Lotso (Ned Beatty), an avuncular pink teddy bear who smells of strawberries (so we're told, the movie is discreetly 3D but not in smell-o-vision).

It's at this point that a slow-starting story hits its stride. Loveable, huggable Lotso makes a terrifically malignant bad guy, a tin-pot dictator whose loathsome lackeys include a baby with a beady eye and a head capable of 360 degree rotations right out of "The Exorcist"; a scary cymbal monkey who doubles as an alarm system; and -- yuck -- a Ken doll. Lotso's wicked plan? To confine the new guys to the toddler room, a charnel house of free play just a short hop from the landfill.

A great escape movie, "Toy Story 3" funnels the series' abiding separation anxiety into a succession of ingenious feints and evasions, climaxing in an apocalyptic vision of the gaping inferno.

Thrilling enough to goose smaller kids, the film is more likely to give sleepless nights to their parents. After all, it's the older folk who are left behind, like Woody, when the kids head off to college.

So now you're abandoned and redundant, wondering whether it's OK to go see the latest Pixar without a youngster in hand. Yes, it's OK; you owe it to yourself.

I seriously doubt there will be a more hilarious and heartfelt blockbuster all summer.

Acting Kyrgyz president says death toll likely much higher

Osh, Uzbekistan (CNN) -- The acting president of Kyrgyzstan said when it comes to the recent ethnic clashes in her country, she would "multiply the official [death] figure by ten," according to the Russian news website Kommersant.

Roza Otunbayeva told Kommersant many deaths in the countryside were not part of the official total of yet, which the Kyrgyz news agency Kabar places at 191, according to the Kyrgyz Health Care Ministry.

In a separate interview in Osh, the iterim president called for reconciliation between the Kyrgyz and Uzbeks.

"By all means, we have to give hope that we shall restore the city, return all the refugees and create all conditions for that. I think the entire world will be helping us, because we two peoples have the goodwill to live in peace and friendship together," said Otunbayeva.

A U.S. official on Friday called for a "substantial" investigation into the killings. Assistant Secretary of State Robert Blake was at a refugee camp near the border in Uzbekistan, where thousands of ethnic Uzbeks fled violence in neighboring Kyrgyzstan.

Blake said he wants Kyrgyzstan authorities to investigate who carried out the attacks on ethnic Uzbeks and to bring those responsible to justice. He planned to go to the Kyrgyz capital of Bishkek later Friday to deliver the message personally, he said.

Blake praised the Uzbek government for working to support the refugees who have flooded into their country. About 120,000 have crossed the border into Uzbekistan, far more than officials had been expecting.

The Obama administration is committed to assisting the Uzbek government with supplies and other aid, Blake said at the camp near Yor Kishlok, where refugees were living in rows of tents.

Refugees were telling stories about the violence that began last week, describing houses and businesses burned by rampaging militias, bodies in the streets and how their relatives had been killed.

Video and witness accounts were starting to emerge Friday that units of the Kyrgyz military may have been taking part in the violence. Refugees on both sides of the border said they are frightened of the Kyrgyz military.

Ethnic violence has displaced about 300,000 people inside Kyrgyzstan, The Office of the U.N. High Commissioner for Refugees said Thursday, citing information from the Kyrgyz interim government and nongovernmental organizations.

Some relief for those refugees is imminent. The UN refugee agency said Friday it will begin airlifting supplies into Kyrgyzstan this weekend. UNHCR plans to send two cargo planes to the southern Kyrgyz city of Osh with enough assistance to help about 15,000 people, with one arriving Saturday and the other Sunday.

Families and host communities were sheltering many of them, but at least 40,000 people were in need of shelter, according to the UNHCR.

The violence between Kyrgyz and Uzbeks in southern Kyrgyzstan has calmed down after it erupted late last week. The UNHCR said in addition to the dozens of deaths around 1,900 have been wounded.

The agency said the situation in Osh and nearby villages "appears to be volatile" and conditions in Jalal-Abad are tense. Many families have left Osh and Jalal-Abad for Bishkek and other areas.

The flood of refugees into Uzbekistan has strained the country's health care and food sectors, and several dozen female refugees crossed the border pregnant and have given birth, the United Nations said.

China, which borders Kyrgyzstan on the east, said Thursday it had removed 1,299 Chinese nationals, the state-run news agency Xinhua said.

The clashes in Kyrgyzstan, which started last week, were part of the most serious outbreak of ethnic violence in the former Soviet republic since 1990, when hundreds of people died in skirmishes between Uzbeks and Kyrgyz in Osh.

The United Nations and several countries, including the United States, Germany and Russia, have sent aid to the region. Francois Blancy, deputy head of the Red Cross regional office in Uzbekistan, said more aid is needed.

"We are now at the peak of the humanitarian crisis," Blancy said Thursday.